Articles Tagged With:
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Acetaminophen Use During Pregnancy and Neurodevelopmental Disorders
The synthesized evidence on prenatal acetaminophen exposure and neurodevelopmental outcomes highlights modest and inconsistent associations and emphasizes that causality remains unproven because of confounding and measurement biases. The authors conclude that, consistent with American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine guidance, acetaminophen remains appropriate in pregnancy when clinically indicated.
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Long-Term Outcomes of Peripartum Cardiomyopathy
A large, prospective, observational study from Israel of peripartum cardiomyopathy has shown that, in general, outcomes are favorable, with high rates of left ventricular function recovery that remain stable and with no mortality but also that show high rates of cardiovascular comorbidities during long-term follow-up.
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Early vs. Late Catheter Ablation for Atrial Fibrillation in Older Patients
An observational study from China in older patients with persistent atrial fibrillation (AF) has shown that an earlier diagnosis to catheter ablation time of ≤ 12 months compared to > 12 months is associated with lower rates of AF recurrence and adverse cardiovascular outcomes.
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Ablation vs. Drugs for Ventricular Tachycardia
A sub-analysis of the VANISH2 trial, which compared catheter ablation (CA) to antiarrhythmic drug therapy for the suppression of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy has shown that in the sotalol therapy group, those randomized to CA less frequently experienced the VT-based composite endpoint. Conversely, in the amiodarone group, the primary endpoint was similar in the CA- and drug therapy-randomized patients, but amiodarone produced more adverse events.
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Improved Major Arrhythmic Event Prediction in Non-Ischemic Cardiomyopathy
An international multicenter registry study of patients with non-ischemic cardiomyopathy without a history of major arrhythmic adverse cardiac events (MAACE) that compared a new cardiac magnetic resonance imaging score for predicting MAACE and consequently determining the need for a primary prevention implantable cardioverter defibrillator has found that this new score is superior to the standard left ventricular ejection fraction criterion.
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Novel Drug-Coated Balloon Compares Favorably to DES in De Novo Disease and ISR
In two related largest-to-date clinical trials, a sirolimus-eluting balloon was noninferior to current-generation drug-eluting stents (DES) in both de novo lesions and in-stent restenosis (ISR).
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Opioid Use Disorder in the ED: A Case-Based Approach
The emergency department (ED) is a critical touchpoint for identifying, initiating, and linking patients with opioid use disorder (OUD) to ongoing care.
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The History Matters!
How would you interpret today’s 12-lead electrocardiogram and long lead V1 rhythm strip if the history was that of an older adult with known coronary disease? Would your interpretation change if, instead, the patient was a younger adult with a known history of severe congenital heart disease, having been operated on a number of times as a child?
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Paltusotine (Palsonify) Tablets
The U.S. Food and Drug Administration has approved paltusotine, the second oral (after octreotide), but first once-daily formulation for the treatment of acromegaly in adults.
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Recombinant Herpes Zoster Vaccine in a Medicare Population
Receipt of adjuvanted recombinant herpes zoster vaccine was effective in individuals older than 64 years of age and maintained its efficacy in immunocompromised individuals. Added benefit accrued from receipt of the second vaccine dose, even if its administration was delayed.